Children and young adults with cystic fibrosis (CF) whose lung infections were treated with suboptimal doses of antibiotics had fewer changes in lung microbial diversity during the IV treatment, and their microbial diversity levels were higher 30 days later, a multi-institutional study that includes Children's researchers shows. By contrast, patients who were treated with therapeutic doses had greater decreases in lung microbial diversity and significantly lower diversity levels when the antibiotic treatment ended as well as 30 days later.
- When study participants were well
- While they were having an APE
- Right after their antibiotic course ended and
- Again at least 30 days later.
They ran each sample through genetic testing to determine the types of bacteria present and their relative abundance. The research team also collected blood samples from each patient while they underwent their antibiotic courses, as well as data on their lung function.